Wilprafen is an antibacterial drug of the macrolide group. It has a bacteriostatic effect due to inhibition of protein synthesis by bacteria. The drug is highly active against a large number of intracellular microorganisms and gram-positive aerobic bacteria.

The antibiotic has no analogues cheaper in terms of the active substance, but with the permission of the doctor, it can be replaced with drugs that are similar in indications and their pharmacological action.

In addition to the antibiotic Vilprafen, there is the drug Vilprafen Solutab, according to the active substance, pharmacological action and indications, they are absolutely identical, the only difference is in the form of release and dosage.

Wilprafen

The active ingredient of the drug is josamycin, release form: tablets, suspension, dispersible tablets (dissolving in the oral cavity).

Indications for use - infectious and inflammatory diseases caused by microorganisms sensitive to the drug:

• scarlet fever (in case of hypersensitivity to penicillins);
• infections of the upper respiratory tract and upper respiratory tract (including pharyngitis, tonsillitis, laryngitis, tonsillitis, paratonsillitis, sinusitis, sinusitis, otitis media);
• lower respiratory tract infections (chronic and acute bronchitis, community-acquired pneumonia);
• diphtheria (in addition to diphtheria antitoxin therapy);

The antibiotic, according to the instructions, is allowed during pregnancy and lactation strictly as directed.

Side effects: rarely - nausea, lack of appetite, vomiting, heartburn, dysbiosis, diarrhea; in some cases - an increase in the activity of hepatic transaminases, jaundice and impaired outflow of bile, urticaria, hearing impairment, candidiasis.

Analogs

Doxycycline (Doxal, Doxycycline Hydrochloride, Doxycycline-Akos, Doxycycline-Ferein)

Available in the form of capsules, lyophilisate; the active ingredient is doxycycline hydrochloride.

A tetracycline antibiotic with a broad spectrum of action, indicated for many infectious and inflammatory diseases.

Capsules for adults and children over 12 years old (weighing more than 45 kilograms) are prescribed in an average daily dose of 200 milligrams on the first day, then 100 milligrams per day. Depending on the severity of the disease, the maximum daily dose for adults is 1 milligram for 5 days.

Side effects: dizziness, anorexia, blurred vision, constipation, nausea, rash, dermatitis, urticaria, myalgia, abnormal liver function.

Clarithromycin (Klacid, Klabaks OD, Clarexid, Claricin, Ecositrin, Fromilid UNO, Fromilid)

Available in tablets, capsules; the active ingredient is clarithromycin.

A broad-spectrum antibiotic used in the treatment of infectious and inflammatory diseases: infections of the upper and lower respiratory tract, ENT organs, skin and soft tissues, odontogenic and mycobacterial infections.

Adults and children over 12 years old are prescribed a single dose of 0.25-1 grams, divided into 2 doses; children under 12 years old - 7.5-15 milligrams / kilogram / day in 2 divided doses. Maximum daily doses: for children - 1 gram, adults - 2 grams.

Side effects: diarrhea, nausea, vomiting, abdominal pain, dyspepsia, gastritis, stomatitis, skin rash, urticaria, dermatitis, insomnia, headache, drowsiness, hypersensitivity, intense sweating, deafness, anorexia, asthma.

Metronidazole (Metronidazole Nycomed, Trichopolum, Flagil, Klion)

Available in the form of tablets, suppositories, solution, gel; the active ingredient is metronidazole.

The drug is used for the treatment of intestinal infectious diseases (including amoebic liver abscess, dysentery) and genital area (chlamydia, bacterial vaginosis) in adults, children, as well as during pregnancy and lactation.

The doctor prescribes the dosage regimen individually, depending on the disease and the severity of its course, as well as the patient's age. The tablets should be taken orally during or after meals, without chewing and drinking water or milk. The average duration of admission is 10 days. In the case of a severe course of the disease, the doses can be increased, and Metronidazole is additionally prescribed to women in the form of suppositories (for example, with trichomoniasis).

Side effects: nausea, diarrhea, anorexia, constipation, dry mouth, dizziness, weakness, headache, depression, irritability, cystitis, candidiasis, urticaria, skin flushing, nasal congestion.

Roxithromycin (Roxid, Rovenal, Brilid, Roximizan, Elrox, Rulid, Xitrocin, Roxibel)

Available in the form of tablets, capsules; the active ingredient is roxithromycin.

Semi-synthetic macrolide has a bacteriostatic effect. It is prescribed for infectious lesions of the upper and lower respiratory tract, bacterial infections of the ENT organs, urinary system. The medicine is also used for diphtheria, scarlet fever, whooping cough, erythematous rashes, periodonitis.

Tablets and capsules must be taken before meals with water. For adults and children over 12 years of age (weighing over 40 kilograms), the standard dosage is 150 milligrams twice a day or 300 milligrams once. If necessary, the doctor can adjust the dose.

Side effects: vomiting, nausea, diarrhea, pancreatitis, headache, rash, temporary hearing loss, impaired smell, bronchospasm, candidiasis.

Spiramycin-Vero (Rovamycin, Spiramisar)

Available in pill form; the active substance is spiramycin.

The antibiotic has a bacteriostatic effect and is indicated for toxoplasmosis, acute bronchitis, exacerbation of chronic bronchitis, community-acquired pneumonia, sinusitis, rhinitis, tonsillitis, urethritis and other infectious and inflammatory diseases.

Adults and children over 18 years of age are prescribed 1 tablet twice a day for 5-7 days. The maximum daily dose is 3 tablets. The medicine should be taken before meals with plenty of fluids.

Side effects: paresthesia, prolonged QT interval, acute hemolysis, thrombocytopenia, Quincke's edema, pruritus, rash, nausea, diarrhea, vomiting, cholestatic hepatitis.

Sumamed (Azithromycin, Azithromycin-OBL, Azilid, Zitrolide, Azitrox, Hemomycin)

Available in the form of capsules, powder, tablets, lyophilisate; the active ingredient is azithromycin dihydrate.

Antibiotics of the macrolide group are prescribed for infectious and inflammatory diseases caused by microorganisms that are sensitive to the drug: infections of the upper and lower respiratory tract, skin and soft tissues, urinary tract, etc.

Capsules and tablets are taken orally 1 hour before or 2 hours after meals without chewing. Adults and children from 12 years old are prescribed 500 milligrams 1 time in 24 hours for 3-5 days, depending on the nature of the disease. For children from 3 to 12 years old, the medicine is prescribed at the rate of 10 milligrams / kilogram of weight 1 time per day for 3 days. Babies from 6 months to 3 years old are prescribed a suspension of 2.5-5 milliliters once a day.

Side effects: candidiasis, leukopenia, anorexia, headache, drowsiness or insomnia, anxiety, irritability, visual impairment.

Flemoxin Solutab (Amoxicillin, Amoxicillin Sandoz, Amosin, Ecobol)

Available in dispersible tablet form; the active ingredient is amoxicillin.

An antibiotic of the penicillin group with a broad spectrum of antimicrobial activity. Indications: bacterial infections of the respiratory system (pneumonia, tonsillitis, sinusitis, pharyngitis, acute inflammation of the middle ear), organs of the genitourinary system (pyelitis, urethritis, pyelonephritis, endometritis, cervicitis), skin and soft tissues (erysipelas, impetigo, secondary infected dermatoses), organs of the digestive system and abdominal infections (dysentery, cholecystitis, typhoid fever).

The tablets can be swallowed whole or pre-dissolved in water. The doctor prescribes the dosage individually, depending on the course of the disease, the patient's age and the sensitivity of the pathogen to the agent.

Side effects: rarely - vomiting, nausea, dysbiosis, stomatitis, crystalluria, leukopenia, eosinophilia, anxiety, insomnia, headache, convulsions, shortness of breath, skin rashes and others.

Ceftriaxone (Rocefin, Azaran, Cefaxone, Ceftriaxone Kabi)

It is produced in the form of a powder for the preparation of a solution for injection; the active ingredient is ceftriaxone.

An antibiotic of the cephalosporin group, like Vilprafen, is indicated for the treatment of many infections: meningitis, sepsis, skin and soft tissues, ENT organs, etc. The drug is administered intravenously or intramuscularly.

Adults and children over 12 years of age are prescribed 1-2 grams 1 time per day; newborns depending on body weight.

Side effects: rash, bronchospasm, fever, nausea, diarrhea, vomiting, flatulence, stomatitis, leukopenia, renal dysfunction, phlebitis, etc.

Tsifran (Tsiprolet, Ciprofloxacin, Tsiprinol, Tsiprobay)

Available in the form of tablets and solution; the active ingredient is ciprofloxacin hydrochloride.

Indications for the use of an antibiotic of the fluoroquinolone group are infectious and inflammatory diseases, including pathologies of the respiratory tract, pelvic and abdominal organs, bones, skin, joints; ENT infections, therapy of postoperative infections. For local use: subacute and acute conjunctivitis, blepharitis, keratitis, meibomitis, and so on.

Doses are prescribed individually. The duration of treatment is from 7-10 days to 4 weeks. The course of treatment is 1-2 weeks.

Side effects: dizziness, sleep disturbance, nausea, vomiting, abdominal pain, crystalluria, dysuria, tachycardia, neutropenia, Quincke's edema, urticaria and others.

Erespal (Erispirus, Epistat, Codetim, Eladon)

Available in the form of tablets, syrup; the active ingredient is fenspiride hydrochloride.

A drug with antibronchoconstrictor and anti-inflammatory activity is used for diseases of the lower and upper respiratory tract: laryngitis, rhinopharyngitis, tracheobronchitis, bronchial asthma, bronchitis, respiratory phenomena (hoarseness, cough, sore throat), with whooping cough, measles and flu, of various origins.

For adults and children over 18 years of age, Erespal is prescribed 1 tablet 2-3 times a day. The maximum daily dose is 240 milligrams. Children are advised to take the drug in the form of a syrup per kilogram of body weight.

Side effects: nausea, diarrhea, dysbiosis, moderate tachycardia, drowsiness, abdominal pain, urticaria, rash, increased fatigue.

Unidox Solutab (Xedocin)

Available in pill form; the active ingredient is doxycycline monohydrate.

An analogue of Vilprafen Solutab. An antibacterial drug of the tetracyclines group of a broad spectrum of action is used for the treatment of infectious and inflammatory diseases: infections of the respiratory tract, ENT organs, sexually transmitted infections, genitourinary system, gastrointestinal tract, etc.

The tablets are taken with meals, after dissolving in a small amount of liquid (20 milliliters). The average duration of treatment is 5-10 days. Dosages are prescribed by the doctor based on the age and weight of the patient, the severity of the disease.

Side effects: anorexia, dysphagia, esophageal ulcer, dermatitis, urticaria, anaphylactic reactions, pericarditis, neutropenia, vestibular disorders, candidiasis, etc.

Contraindications: pregnancy, breastfeeding, porphyria, severe renal and / or liver dysfunction, age up to 8 years, hypersensitivity.

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Vilprafen's analogs: cheaper and better

Review of cheap substitutes

Modern society gets sick very often. A lot of money is spent to alleviate the condition. There are many drugs, but few effective ones. Wilprafen is considered quite popular. At a price of 520 rubles, so not everyone can afford to use it.

Wilprafen is an antibiotic, the main element of which is a macrocyclic 16-membered lactone ring with one or more carbohydrate residues attached to it. Thanks to him, they treat thrush in men. Due to the violation of protein synthesis on the ribosomes of the microbial cell, it acts as an antimicrobial, anti-inflammatory, bacteriostatic agent, and also increases the body's resistance to pathogens. Modern technologies make it possible to reproduce with the same auxiliary substances, but at a cheaper price.

What can replace Vilprofen?

This drug has a domestic and foreign substitute. Let's try to make out in detail which is better.

Foreign counterparts

• Vilprofen solutab its difference from vilprofen is that in each tablet the content of the active substance is 1000 mg, and not 500, as in the usual one. Thus, the intake of the medicine is reduced. Also, I would like to note that the manufacturer of the first is Holland, the second is Holland and Germany. It costs about 500 rubles.
• Metronidazole - tablets 250 mg, protozoal infections, reproductive system. From 10 rubles.

Do not prescribe for: anemia, intolerance to the components of the drug, an unstable state of the brain, lactation, pregnancy for the first 3 months, kidney problems.

• Tsifran - for inflammation of the middle ear and paranasal sinuses of the nose, eyes, abdominal organs, bacterial infections of the gastrointestinal tract, gallbladder, kidneys, pelvic organs, skin, bones and joints, including purulent ones.

Contraindications: sensitivity to the drug, age group under 18, women expecting a baby, breastfeeding.

• Roxibel - tablets 150 mg for infections of the upper and lower respiratory organs, dermal suppuration, non-gonococcal urethritis.

• Sumamed - can be bought in capsules, powder and tablets from 50 rubles. Treatment of infections of the upper and lower respiratory tract, skin and soft tissues, urinary system, gastrointestinal tract.

• Flemoxin solutab - tablets against infectious diseases of the respiratory system, genitourinary system, skin, gastrointestinal tract. Price from 220.

• Erythromycin - tablets with bacteriological action. In pharmacies from 110 rubles. It is taken for the treatment of infections of the upper and lower respiratory tract, gastrointestinal tract, vision, skin, genitourinary system, including sexually transmitted infections.

Who is not prescribed: nursing mothers taking terfenadine, astemizole, purulent ear infections. With care: abnormal liver and kidney function, heart rhythm failure, hepatitis C.

Cannot be administered to: children under 18 years of age, pregnancy, lactation, severe sensitivity to the components.

• Ceftriaxone-AKOS - for purulent inflammation of the skin, internal organs, respiratory tract, bone tissue, joints, reproductive system.

Do not give for allergies, during pregnancy, breastfeeding, children under 12 years of age. The pharmacy can be purchased from 20 rubles.

• Doxycycline - 100 mg capsules, prescribed for inflammation of the respiratory tract, genitourinary tract, gastrointestinal tract, sexually transmitted diseases, diseases associated with the skin, hearing organs, eyes. From 23 rubles.

• Clarithromycin - 250 mg tablets, prescribed for the treatment of diseases, the pathogens in which die when exposed to clarithromycin. Price from 70.

Contraindications: advanced kidney disease, pregnancy 1 trimester, breastfeeding, hepatitis, taking medications - cisapride, astemizole, pimozide, allergies.

As you can see, analogues are cheaper than foreign pharmaceutical companies, but you can also pick up a Russian analogue. Only a specialist will be able to prescribe a suitable analogue of Vilprafen tablets, both in price and in quality.

Important information: clarithromycin, vilprafine, and spiramycin can be taken with or without food, while other macrolides can be taken 2 hours after or 1 hour before meals. Erythromycin (when taken orally) is taken with plenty of water.

It's just elementary! To return and strengthen potency, you need every evening.

Reviews for Wilprafen

After reading all the reviews, we can say that the drug is very good. Among the positive qualities, efficiency, rapid excretion from the body was noted, which is allowed to be taken during pregnancy.

The disadvantage here is the high price. It is a broad-spectrum antibiotic, therefore it is used both for treatment and for the prevention of many infectious diseases. None of the patients noticed anything about side effects. The course of therapy is prescribed only by a qualified specialist after a complete examination.

Analogues of the drug Vilprafen - a review of drugs

Vilprafen Solutab is the trade name of the macrolide antibiotic josamycin, which is used primarily for the treatment of bacterial pathologies of the ENT organs. Over time, it was also found that this drug acts much more broadly, which led to a significant expansion of indications for use.

Wilprafen characteristic

Vilprafen Solutab has a good bacteriostatic effect due to its ability to inhibit the work of the 50S-subunit of the ribosome of microbes. This leads to the inability of further multiplication of pathogenic bacteria, as well as a decrease in their resistance to the body's immune response.

It acts on staphylococci, streptococci, neisseria, pneumococci, corynebacteria, mycoplasma, chlamydia, treponema and rickettsia.

The pharmacological features of josamycin are special. The drug molecules are well absorbed when taken orally. For intramuscular or intravenous administration, Vilprafen Solutab is not used. Antibiotic particles accumulate in inflamed tissues, where their concentration can exceed the amount of the drug in the blood several times. Vilprafen is excreted from the body mainly by the kidneys in an unchanged state, which makes it possible to use it for infections of the genitourinary system.

Vilprafen Solutab is prescribed under the following conditions:

• tracheitis;
• acute and chronic bronchitis;
• community-acquired pneumonia without complications;
• sinusitis;
• otitis media;
• pharyngitis;
• tonsillitis (including diphtheria);
• dental bacterial pathologies;
• urethritis;
• cystitis;
• chlamydia;
• gonorrhea;
• bacterial processes of soft tissues.

When using Vilprafen, side effects are rarely observed. Sometimes allergic reactions of varying severity occur (however, much less often than with the appointment of beta-lactam antibiotics).

Cases of a transient increase in the concentration of bilirubin and hepatic enzymes in the peripheral blood, the development of toxic hepatitis, hearing loss, general fatigue and the appearance of edema of the lower extremities are described.

The drug has a rather small list of contraindications, which includes individual intolerance to the components of the drug, impaired renal function, pregnancy and lactation in women.

Also, neonatologists do not advise prescribing Wilprafen during the newborn period of a child.

Vilprafen Solutab is prescribed for adults 2-3 times a day, depending on the severity of the pathology. For children, the dosage of the antibiotic must be individually calculated based on their age and body weight. Their usual daily dose is 50 mg / kg. The duration of the course of treatment is from 5 to 14 days.

Vilprafen's analogs

Azithromycin

Azithromycin, like the Vilprafen analog, is an antibacterial agent from the macrolide antibiotic group. The drug is a member of the azalide subclass, which introduces several features in the pharmacological characteristics of the antibiotic.

The drug has a bacteriostatic effect, like josamycin. The mechanism of action of these medicines is also identical. However, the spectrum of sensitivity to azithromycin is somewhat narrower. In this antibiotic, the ability to accumulate in the inflamed tissues of the body is more pronounced, in which its therapeutic concentration remains up to 72 hours. This allows you to reduce the frequency and course of antibiotic treatment.

As with other Vilprafen analogues, the indications for the appointment of azithromycin are almost identical. Azithromycin - as one of the safest and most effective antibiotics, is now included in the treatment protocols for all antibacterial pathologies of the respiratory system and ENT organs.

He is given an advantage when penicillins are ineffective, or there is hypersensitivity to beta-lactam drugs (in addition to penicillins, this also includes cephalosporins, monobactams, carbapenems).

Also, azithromycin is part of the combination therapy for peptic ulcer disease for the eradication of Helicobacter pylori infection.

You can not prescribe azithromycin under the following conditions:

• individual intolerance to the drug;
• liver failure;
• the presence of a congenital tendency to tachyarrhythmias of the heart.

During pregnancy, azithromycin is prescribed in cases where it cannot be replaced with a drug with a safer profile. In renal failure, it is necessary to carefully select the dosage of the drug based on the glomerular filtration rate. It is advisable to monitor the concentration of the antibiotic in the blood plasma.

Azithromycin is prescribed for adults 500 mg once a day. Most pathologies require a 3-day course of therapy, but if necessary, it can be continued. For children, a special form of antibiotic in the form of a syrup has been developed, which also simplifies the dosage of the drug.

Klacid

If we are talking about Vilprafen's analogues, then it is necessary to say about Klacid. This drug also belongs to the group of macrolide antibiotics. Its active ingredient is clarithromycin. Like other representatives of this class of medicines, Klacid has a bacteriostatic effect. But unlike josamycin, this drug does not have an effective effect on the causative agents of urogenital infections.

However, Klacid inhibits almost the entire spectrum of mycoplasma and Helicobacter pylori infections.

In the body, clarithromycin accumulates in the affected tissues, but is excreted much faster than azithromycin. At the same time, the drug shows the greatest efficiency with neutral acidity. Therefore, for the treatment of H. pylori infection, it must be combined with drugs that would lower the production of gastric juice (proton pump inhibitors are most suitable).

In modern recommendations, clarithromycin is of greatest importance as a remedy for the treatment of mycobacterium, legionella and Helicobacter pylori pathologies. It is also used for bacterial infectious processes of the respiratory system and ENT organs.

Klacid is contraindicated to use if the patient has the following conditions:

• allergies to drugs of the macrolide group;
• ventricular tachyarrhythmias or a high risk of developing them;
• hypokalemia;
• liver failure;
• concomitant use of ticagrelor after myocardial infarction;
• use of colchicine.

The most common side effects when taking Klacid are:

• a transient increase in the concentration of bilirubin and hepatic enzymes in blood plasma;
• allergic reactions of varying severity;
• accession of a secondary bacterial, viral or fungal infection;
• development of cardiac tachyarrhythmias;
• oppression of hematopoiesis (with clinical symptoms of anemia, internal or external hemorrhage, secondary infections);
• toxic effect on the central nervous system (headache, dizziness, parasthesia);
• functional disorders of the digestive system (nausea, vomiting, feeling of heaviness in the abdomen, decreased appetite, diarrhea).

During lactation and pregnancy, the drug is not advised to use.

The course of treatment depends on the etiology of the bacterial process. With Helicobacter pylori infection, the course of treatment lasts at least 14 days, with most diseases of the respiratory system 3-7, and with mycobacterial infection - from 10 days.

Amoxicillin

Amoxicillin is an antibacterial agent belonging to the group of synthetic penicillins. Unlike penicillin, this drug has a pronounced bactericidal effect. Its molecules are capable of disrupting the integrity of the cell membranes of pathogenic pathogens, which leads to their death and lysis.

The drug actively acts on staphylococci, streptococci, pneumococci, corynebacteria, haemophilus influenzae, clostridia, listeria, salmonella, shigella, E. coli, proteus, klebsiella, moraxella. This allows the antibiotic to be used for a wide range of bacterial infections of the respiratory and digestive systems.

When taken orally, the drug is partially absorbed. The therapeutic concentration of amoxicillin is maintained for 3-4 hours after administration. This is due to the 3-time frequency of antibiotic use per day.

Amoxicillin is used for bacterial pathologies of the respiratory system (tracheitis, bronchitis, out-of-hospital pneumonia), ENT organs (otitis media, sinusitis, pharyngitis, tonsillitis), intestinal infections (salmonellosis, shigellosis), cholecystitis, urethritis, and cystitis after surgery ...

When prescribing amoxicillin, more often than other analogues, allergic reactions occur (rash with severe itching, dyspeptic disorders, Quincke's edema or anaphylactic shock). Therefore, before prescribing, it is imperative to clarify with the patient whether he has previously had hypersensitivity reactions to beta-lactam antibiotics (penicillins, cephalosporins, monobactams and carbapenems).

In addition, the following side effects occur:

• sleep disturbance;
• headache and dizziness;
• dyspeptic disorders;
• toxic hepatitis and yellowness of the skin;
• oppression of hematopoiesis.

Despite these side effects, amoxicillin is considered a safer antibacterial drug than macrolides.

It is allowed to be used as a substitute for Wilprafen during pregnancy. However, it also has its drawback - many strains of bacteria have developed resistance to its action. What is better in each specific situation should be decided by a qualified doctor.

Amoxicillin is prescribed in the form of tablets for adults and syrup for children under 6 years of age.

Analogs. Treatment of diseases. Probiotics. Advice. Question answer. .serp-item__passage. The drug Vilprafen Solutab belongs to the antibiotics of the macrolide group.

Doxycycline and its analogues (in particular, Unidox Solutab). ... Vilprafen cannot be used in parallel with treatment with drugs such as

What drugs are analogues of the drug Hemomycin. ... Vilprafen drug analogues - a review of drugs.

Vilprafen analogs - a review of drugs. Review of drugs analogous to the antibiotic Rovamycin.

Review of antibiotics - analogues of the drug Rovamycin. ... Vilprafen analogs - a review of drugs.

Josamycin and its analogs belong to the macrolide group. These drugs have a bactericidal effect. The active substance interacts with the 50S subunit, preventing the retention of transport RNA and suppressing protein synthesis.

What can replace Josamycin?

The medicine is indicated for chronic and acute infections caused by a violation of microflora. To restore normal functioning, drugs based on josamycin are often used. Often this is a medicine of the same name. It affects the body in a certain way, removing many of the symptoms. Although cheaper analogs of Josamycin are often prescribed.

For example, Wilprafen is considered the most common. These are pills. It is indicated for the treatment of:

• tonsillitis, otitis media, sinusitis and other ailments associated with an upper respiratory tract infection;
• diphtheria;
• , whooping cough;
• urethritis, prostatitis;
• chlamydial and mixed urinary tract infections.

In addition, Wilprafen solutab is considered the main generic drug of Josamycin. This drug is a complete analogue. It also has antibacterial and bactericidal properties. But there is still a difference - the tablets are produced in an oblong shape, they are sweet and have a strawberry smell.

Antibiotics of the macrolide group are also considered analogs of this drug:

• erythromycin;
• clarithromycin, which can be found in pharmacies under such names as Binoclar, Clarbact, Claricin, Clarosil, Fromilid;
• azithromycin - Azivok, Azitral, Zimax, Sumazid, Hemomycin;
• roxithromycin - Brilid, Remora, Roxid, Elrox;
• spiramycin - Rovamycin;
• midecamycin - Macropen, Medicamecin acetate.

What kind of medicine is suitable for a particular patient, only specialists will be able to find out for sure, based on the test indicators. You can often hear that if the pharmacy does not have the necessary drug, then it can be safely replaced with another. But this is not 100% true. In each case, a doctor's consultation is needed.

Which is better - Josamycin or Azithromycin?

Many prescribe these drugs without hesitation: they have an almost identical active substance, and therefore their effect. the same. Despite this, based on international studies, we can safely say that leads to a lesser extent to the manifestation of such side effects as.

Patients' perception of what drug analogues are somewhat different from the official version adhered to by doctors and pharmacists. Therefore, before finding out whether there are analogues of wilprafen, one should figure out what it is and how the analogues differ from synonyms.

Analogues and synonyms of drugs

It is correct to call analogs drugs that belong to the same group of drugs and can replace each other. The active active substance of such drugs is different, but the drugs work similarly. At the same time, analog drugs may have significant differences, and therefore, it is preferable to prescribe this or that drug for a certain disease. Therefore, only a doctor can replace a prescribed drug with an analogue.

Synonyms are drugs that have the same active ingredient, so the patient can replace it himself, having received the advice of a pharmacist at a pharmacy.

Unfortunately, in the minds of many patients, analogs are drugs that actually belong to the group of synonyms, that is, they have the same active active ingredient. This creates confusion and often the patient does not understand why he is given a drug with a different name in the pharmacy instead of the medication prescribed by the doctor.

In this case, you should be guided by the international non-proprietary name (INN), which is necessarily indicated under the corporate (invented by this pharmaceutical company) small print.

It is the INN that indicates the active active ingredient that is part of the drug.

Does wilprafen have analogues

Wilprafen is a drug from the macrolide group. If we adhere to the official version of the definition, then antibiotics of the macrolide group belong to the analogues of wilprafen. It:

Only a doctor can decide whether a particular drug can replace Vilprafen, taking into account the underlying and concomitant diseases, the patient's condition, side effects of the drug, and so on.

Does Wilprafen have synonyms

Vilprafen has no synonyms. Josamycin is no longer included as an active ingredient in any medicinal product. But wilprafen is available in different dosage forms, allowing you to choose the one that is best suited for a given patient:

From these dosage forms in the pharmacy, with the help of a pharmacist, you can choose the most suitable one and calculate how much medicine you need to take in accordance with the doctor's prescription.

How macrolides work

The mechanism of action of macrolides is associated with the suppression of protein synthesis in the bacterial cell. Usually macrolides have a bacteriostatic effect (suppress the vital activity of bacteria), but in high concentrations they can act bactericidal (kill bacteria).

In addition to antimicrobial action, macrolides have immunomodulatory and some anti-inflammatory properties.

Release form

Operating principle

The medication is active against:

Contraindications

Side effects

Overdose

Terms of sale

Storage features

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Vilprafen Solutab for children: instructions for use

Release form

The main component of anbitiotic Vilprafen Solutab is represented by josamycin. Its dosage per tablet is 1000 mg. To make the drug solid, keep its shape and dissolve in water, colloidal silicon dioxide, hyprolose and magnesium stearate, as well as sodium docusate and microcrystalline cellulose are added to it. Strawberry flavor and aspartame are included in the preparation for a pleasant taste.

Operating principle

In josamycin, a bacteriostatic effect is noted, due to the binding of this substance to the ribosomes of microbial cells, as a result of which the synthesis of protein molecules is disrupted in bacteria. This leads to a slowdown in the reproduction and growth of microorganisms.

The medication is active against:

In this case, the medicine is often inactive when infected with enterobacteria. It has almost no effect on the normal intestinal microflora. Note also that the drug usually acts on strains of microbes that are resistant to erythromycin and other macrolides.

Treatment with Vilprafen Solutab is prescribed:

At what age is it applied?

Contraindications

Vilprafen Solutab is not prescribed if the child has:

• There is an intolerance to josamycin or other ingredients of the tablets.
• An allergy to any macrolide antibiotic was found.
• The liver is severely impaired.

Side effects

The child's body can react to Vilprafen Solutab by the appearance of:

Rare side effects of this antibiotic include constipation, Quincke's edema, decreased appetite, stomatitis, urticaria, jaundice, hearing impairment, or purpura.

Instructions for use and dosage

Overdose

Interaction with other drugs

• Vilprafen Solutab is not prescribed together with any bactericidal antibiotics, as well as with representatives of the lincosamide group.
• If you take antihistamines (astemizole or terfenadine) at the same time, the risk of heart rhythm disturbances increases.
• It is not advised to combine treatment with josamycin and xanthines, cyclosporine or ergot alkaloids.

Terms of sale

Buying Vilprafen Solutab requires a prescription from a doctor. The average cost of one drug package is 650 rubles.

Storage features

To store the drug, you should find a place where a small child cannot reach the medication. The temperature during storage of the medicine should not exceed 25 degrees Celsius. Dispersible tablets have a shelf life of 2 years.

Mothers respond mostly positively to the treatment of children with Vilprafen in the form of dispersible tablets. They note that the drug quickly helps to get rid of the infection: for example, with pneumonia after taking such an antibiotic, cough, fever and other symptoms disappear within a few days. Complaints about the side effects of the medication are very rare. Most often, among the minuses of a medication, only its rather high cost is called.

Instead of the antibiotic Vilprafen Solutab, the doctor may prescribe another drug from the macrolide group, for example:

You will learn more about antibiotics from the program of Dr. Komarovsky.

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Inexpensive Vilprafen analogues

In addition to the antibiotic Vilprafen, there is the drug Vilprafen Solutab, according to the active substance, pharmacological action and indications, they are absolutely identical, the only difference is in the form of release and dosage.

Wilprafen

The active ingredient of the drug is josamycin, release form: tablets, suspension, dispersible tablets (dissolving in the oral cavity).

Indications for use - infectious and inflammatory diseases caused by microorganisms sensitive to the drug:

The antibiotic, according to the instructions, is allowed during pregnancy and lactation strictly as directed.

Side effects: rarely - nausea, lack of appetite, vomiting, heartburn, dysbiosis, diarrhea; in some cases - an increase in the activity of hepatic transaminases, jaundice and impaired outflow of bile, urticaria, hearing impairment, candidiasis.

Doxycycline (Doxal, Doxycycline Hydrochloride, Doxycycline-Akos, Doxycycline-Ferein)

Available in the form of capsules, lyophilisate; the active ingredient is doxycycline hydrochloride.

A tetracycline antibiotic with a broad spectrum of action, indicated for many infectious and inflammatory diseases.

Side effects: dizziness, anorexia, blurred vision, constipation, nausea, rash, dermatitis, urticaria, myalgia, abnormal liver function.

Clarithromycin (Klacid, Klabaks OD, Clarexid, Claricin, Ecositrin, Fromilid UNO, Fromilid)

Available in tablets, capsules; the active ingredient is clarithromycin.

A broad-spectrum antibiotic used in the treatment of infectious and inflammatory diseases: infections of the upper and lower respiratory tract, ENT organs, skin and soft tissues, odontogenic and mycobacterial infections.

Adults and children over 12 years old are prescribed a single dose of 0.25-1 grams, divided into 2 doses; children under 12 years old - 7.5-15 milligrams / kilogram / day in 2 divided doses. Maximum daily doses: for children - 1 gram, adults - 2 grams.

Side effects: diarrhea, nausea, vomiting, abdominal pain, dyspepsia, gastritis, stomatitis, skin rash, urticaria, dermatitis, insomnia, headache, drowsiness, hypersensitivity, intense sweating, deafness, anorexia, asthma.

Metronidazole (Metronidazole Nycomed, Trichopolum, Flagil, Klion)

Available in the form of tablets, suppositories, solution, gel; the active ingredient is metronidazole.

The drug is used for the treatment of intestinal infectious diseases (including amoebic liver abscess, dysentery) and genital area (chlamydia, bacterial vaginosis) in adults, children, as well as during pregnancy and lactation.

Side effects: nausea, diarrhea, anorexia, constipation, dry mouth, dizziness, weakness, headache, depression, irritability, cystitis, candidiasis, urticaria, skin flushing, nasal congestion.

Roxithromycin (Roxid, Rovenal, Brilid, Roximizan, Elrox, Rulid, Xitrocin, Roxibel)

Available in the form of tablets, capsules; the active ingredient is roxithromycin.

Tablets and capsules must be taken before meals with water. For adults and children over 12 years of age (weighing over 40 kilograms), the standard dosage is 150 milligrams twice a day or 300 milligrams once. If necessary, the doctor can adjust the dose.

Side effects: vomiting, nausea, diarrhea, pancreatitis, headache, rash, temporary hearing loss, impaired smell, bronchospasm, candidiasis.

Spiramycin-Vero (Rovamycin, Spiramisar)

Available in pill form; the active substance is spiramycin.

The antibiotic has a bacteriostatic effect and is indicated for toxoplasmosis, acute bronchitis, exacerbation of chronic bronchitis, community-acquired pneumonia, sinusitis, rhinitis, tonsillitis, urethritis and other infectious and inflammatory diseases.

Adults and children over 18 years of age are prescribed 1 tablet twice a day for 5-7 days. The maximum daily dose is 3 tablets. The medicine should be taken before meals with plenty of fluids.

Side effects: paresthesia, prolonged QT interval, acute hemolysis, thrombocytopenia, Quincke's edema, pruritus, rash, nausea, diarrhea, vomiting, cholestatic hepatitis.

Sumamed (Azithromycin, Azithromycin-OBL, Azilid, Zitrolide, Azitrox, Hemomycin)

Available in the form of capsules, powder, tablets, lyophilisate; the active ingredient is azithromycin dihydrate.

Antibiotics of the macrolide group are prescribed for infectious and inflammatory diseases caused by microorganisms that are sensitive to the drug: infections of the upper and lower respiratory tract, skin and soft tissues, urinary tract, etc.

Side effects: candidiasis, leukopenia, anorexia, headache, drowsiness or insomnia, anxiety, irritability, visual impairment.

Flemoxin Solutab (Amoxicillin, Amoxicillin Sandoz, Amosin, Ecobol)

Available in dispersible tablet form; the active ingredient is amoxicillin.

The tablets can be swallowed whole or pre-dissolved in water. The doctor prescribes the dosage individually, depending on the course of the disease, the patient's age and the sensitivity of the pathogen to the agent.

Side effects: rarely - vomiting, nausea, dysbiosis, stomatitis, crystalluria, leukopenia, eosinophilia, anxiety, insomnia, headache, convulsions, shortness of breath, skin rashes and others.

Ceftriaxone (Rocefin, Azaran, Cefaxone, Ceftriaxone Kabi)

It is produced in the form of a powder for the preparation of a solution for injection; the active ingredient is ceftriaxone.

An antibiotic of the cephalosporin group, like Vilprafen, is indicated for the treatment of many infections: meningitis, sepsis, skin and soft tissues, ENT organs, etc. The drug is administered intravenously or intramuscularly.

Adults and children over 12 years of age are prescribed 1-2 grams 1 time per day; newborns depending on body weight.

Side effects: rash, bronchospasm, fever, nausea, diarrhea, vomiting, flatulence, stomatitis, leukopenia, renal dysfunction, phlebitis, etc.

Tsifran (Tsiprolet, Ciprofloxacin, Tsiprinol, Tsiprobay)

Available in the form of tablets and solution; the active ingredient is ciprofloxacin hydrochloride.

Doses are prescribed individually. The duration of treatment is from 7-10 days to 4 weeks. The course of treatment is 1-2 weeks.

Side effects: dizziness, sleep disturbance, nausea, vomiting, abdominal pain, crystalluria, dysuria, tachycardia, neutropenia, Quincke's edema, urticaria and others.

Erespal (Erispirus, Epistat, Codetim, Eladon)

Available in the form of tablets, syrup; the active ingredient is fenspiride hydrochloride.

For adults and children over 18 years of age, Erespal is prescribed 1 tablet 2-3 times a day. The maximum daily dose is 240 milligrams. Children are advised to take the drug in the form of a syrup per kilogram of body weight.

Side effects: nausea, diarrhea, dysbiosis, moderate tachycardia, drowsiness, abdominal pain, urticaria, rash, increased fatigue.

Unidox Solutab (Xedocin)

Available in pill form; the active ingredient is doxycycline monohydrate.

The tablets are taken with meals, after dissolving in a small amount of liquid (20 milliliters). The average duration of treatment is 5-10 days. Dosages are prescribed by the doctor based on the age and weight of the patient, the severity of the disease.

Side effects: anorexia, dysphagia, esophageal ulcer, dermatitis, urticaria, anaphylactic reactions, pericarditis, neutropenia, vestibular disorders, candidiasis, etc.

Contraindications: pregnancy, breastfeeding, porphyria, severe renal and / or liver dysfunction, age up to 8 years, hypersensitivity.

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The first antibiotic from the macrolide group was Erythromycin. However, bacteria gradually developed resistance to it and therefore this drug is not able to cope with new strains.

Erythromycin was replaced by other macrolides, including the non-toxic antibiotic Vilprafen Solutab, which has a minimum of contraindications and side effects and is therefore prescribed to people of any age.

The drug has been known since the 70s of the 20th century, therefore, it is recommended by WHO as one of the safest, and since 2012 it has been included in the list of vital signs all over the world, which indicates the high confidence of doctors in this antibiotic.

The active ingredient of the drug is josamycin, which effectively copes with many bacteria and therefore is used:

• in dentistry for the treatment of periodontitis and periodontal disease, gingivitis;
• eNT diseases: laryngitis, pharyngitis, tonsillitis, sinusitis, otitis media, diphtheria, sinusitis;
• respiratory diseases: bronchitis, pneumonia, scarlet fever, whooping cough;
• diseases of the genitourinary system, including venereal diseases, in men and women: cystitis, prostatitis, gonorrhea, urethritis, chlamydia, ureaplasma, mycoplasma, pyelonephritis and others;
• skin diseases: boils, acne;
• ophthalmic diseases: blepharitis, dacryocystitis;
• for the treatment of anthrax.

Josamycin is a natural macrolide antibiotic. It is produced by soil bacteria-actinomycetes. The bactericidal effect of this antibiotic is manifested when a sufficient therapeutic dose of the active substance is achieved in the focus of inflammation. Josamycin blocks the delivery of amino acids into bacterial cells, due to this, protein synthesis becomes impossible, which prevents the reproduction of microorganisms, since the division process stops in the nucleus.

Josamycin destroys:

• gram-positive aerobic microorganisms, which require oxygen for nutrition;
• gram-negative bacteria. In some cases, against these bacteria, the drug may be ineffective, but only when new strains of infection appear. However, due to the properties of josamycin, bacterial resistance to it rarely develops, unlike other macrolides.

The active ingredient Wilprafen Solutaba has a slight effect on enterobacteria and this is its great value, since, with its effectiveness against pathogenic bacteria, the antibiotic does not affect the natural microflora of the stomach and intestines. The drug practically does not affect the natural microflora of the genital tract, therefore it does not cause the development of thrush in women.

Josamycin enters the human body through the gastrointestinal tract, but the effectiveness of Wilprafen Solutab does not depend on food intake. This makes this antibiotic even more attractive for use, since the active substance quickly penetrates the body: within 1 hour after administration, the concentration of the drug becomes maximum and a therapeutic effect occurs.

Almost immediately after entering the body and the onset of action against bacteria, the drug begins to be excreted with sweat and tears. Only 20% of the substance is excreted in the urine, and most of it is excreted in the bile. The highest concentration of josamycin according to the research results was recorded in sputum, and not in blood. The antibiotic is unable to penetrate the bone marrow, but accumulates in the bone tissue.

Mode of application

Usually Vilprafen Solutab is prescribed two to three times a day at a maximum concentration of 2 grams. If the concentration of the active substance is selected incorrectly, the drug will be ineffective and the development of bacterial resistance to josamycin is not excluded. Therefore, the minimum dose recommended by the manufacturer of the drug should be at least 1 gram per day.

Doctors recommend starting therapy with small doses, but sufficient for a therapeutic effect. If the patient's condition is severe, he may be prescribed an increased dose of the drug: 3 grams per day. Wilprafen Solutab is preferred by doctors when patients have developed resistance to the action of penicillin antibiotics.

Form of release, composition, dosage and duration of drug therapy

The medication is available in the form:

• tablets of 500 mg josamycin and 1000 mg josamycin;
• water-soluble tablets containing 1 g of josamycin;
• suspensions containing josamycin in 10 ml 300 mg.

When taking the suspension by patients with diabetes mellitus, it must be borne in mind that the drug in this form contains 3.25 g of dextrose. The period of taking the drug is from 5 days to 3 weeks, depending on the disease and the bacteria that the patient is infected with. For example, in order to cope with streptococcal tonsillitis, the medication must be taken within 10 days.

In addition to the active substance, the preparation includes:

• microcrystalline cellulose, which has no effect on the body and is necessary for the formation of the tablet structure;
• hydroxypropyl cellulose is not recommended for children under 16 years of age and people suffering from gastrointestinal diseases. According to some reports, this substance can increase blood cholesterol levels;
• sodium docusate and polysorbate 80 are used only in the composition;
• Vilprofen Salutaba sodium docusate is a water-soluble waxy substance, due to which the tablets dissolve easily within 3 minutes. Polysorbate 80 can cause allergies, and in case of an overdose, it leads to the development of hormonal disruptions;
• silicon dioxide is necessary in the composition of tablets to form the structure;
• magnesium stearate - a filler.

This antibiotic is contraindicated in pregnant women in the first trimester and lactating, since the active substance easily penetrates through the placenta to the fetus and accumulates in breast milk.

If it becomes necessary to treat chlamydial infection in the first trimester of pregnancy, a gynecologist may recommend replacing the drug with Azithromycin. However, in European countries, josamycin is recommended specifically for pregnant women, as the safest. Pregnant women are not recommended to use the drug, because clinical studies on the effect of this antibiotic on the fetus have not been conducted.

The use of this drug is contraindicated:

• together with antihistamines, since an increase in arrhythmia is not excluded, which can threaten the patient's life;
• children under one year old, since josamycin is able to slow down growth and this is one of the reasons why the drug is not recommended for the treatment of children under 14 years old. In severe cases, the medicine can be prescribed to children under 1 year old, but only on condition that their body weight is more than 10 kg. The dose of the drug is calculated for children only by a doctor, taking into account the state of health of the child and based on body weight: 45 mg per 1 kg of body weight;
• simultaneously with penicillin and its derivatives, as well as lincomycin and cephalosporins, since a decrease in the effectiveness of all drugs is possible.

Care should be taken to take the medication during the period of using hormonal contraceptives, since their contraceptive effect may be reduced. If it is necessary to take an antibiotic, it is necessary to use additional barrier methods of contraception.

Despite the fact that the antibiotic with the active substance josamycin has a small list of contraindications, it is not recommended to use it for violations of liver and kidney function, hypersensitivity to excipients in the drug and together with alcohol due to the possibility of increasing the negative effect on the liver.

Among the side effects on the part of digestion, manufacturers note the possibility of nausea, vomiting, diarrhea during the period of use of the drug. According to some reports, the drug may cause hearing impairment. For the most effective treatment, it is necessary to take Vilprafen Solutab every 12 hours in order to maintain the therapeutic concentration of the active substance and with a large amount of water in order to accelerate its dissolution.

Vilprafen Solutab: instructions for use for the treatment of chlamydia

The drug has proven itself well in the treatment of various bacterial sexually transmitted infections, including chlamydia, which is a venereal disease. It is almost impossible to become infected with chlamydia in everyday life.

According to the WHO, about 100 thousand people are infected with chlamydial infection in the world every year.

Women are prone to chlamydia more often than men, who in most cases are carriers of the infection, while they do not show clinical symptoms of infection.

Symptoms of chlamydia in women can be subtle, latent and manifest:

• itching and burning in the genital area, which can be perceived as symptoms of thrush;
• mucopurulent vaginal discharge with an unpleasant odor;
• pain during menstruation.

In men, the infection can manifest itself:

• secretions of a vitreous consistency;
• itching and slight burning sensation during urination;
• periodic pain in the testicles and in the scrotum.

The danger of chlamydia is also that it causes the development of adhesions in the fallopian tubes and can cause ectopic pregnancy and infertility. If pregnancy occurs in the presence of chlamydia, an untreated infection can provoke a miscarriage, premature birth and the development of pathologies in a newborn, since the child becomes infected from an infected mother while passing through the birth canal.

Today, doctors recognize Vilprafen Solutab as the most effective drug for the treatment of chlamydia. The instructions for use do not give precise recommendations on the dosage and timing of therapy for chlamydial infection, therefore, the doctor prescribes a course of treatment individually in accordance with the patient's state of health.

According to reviews, it is this drug that copes with the task after the first course of treatment, but a comprehensive approach is needed for successful therapy, since if improperly treated, the disease will turn into a chronic form and it will be difficult to fight it. If you use Vilprafen Solutab according to the instructions for use, the drug allows you to avoid complications that cause chronic chlamydia, and the success of treatment is achieved in 97% of cases, unlike, for example, Azithromycin (55% of cases).

If the drug is used to treat chlamydia in adolescents, then the dose is calculated based on the child's body weight: 40 mg / kg. Among the patients who used Vilprafen Solutab according to the instructions for use, there were those who noted the manifestation of side effects: weakness, dizziness. If the side effects are severe, it is necessary to consult a doctor who will adjust the dose and treatment regimen. Chlamydial infection is treated with this drug within 7 to 14 days.

Vilprafen Solutab: instructions for use for the treatment of other diseases

Supplied with Vilprafen Solutab instructions with a detailed description of indications, contraindications and dosage.

The instructions say that the drug is indicated for the treatment of infectious and inflammatory diseases caused by microorganisms.

Among the many diseases for which Vilprafen Solutab is effective according to the instructions, there are sexually transmitted diseases: syphilis, gonorrhea. However, it is impossible to treat syphilis and gonorrhea with this drug on your own without laboratory control, since there is a danger of the transition of an untreated disease into a latent stable form, and then it will be much more difficult to choose an effective antibiotic.

According to the instructions, Vilprafen Solutab is also used:

• in combination therapy with other drugs for the destruction of Helicobacter pylori infection with stomach ulcers at a dosage of 1 mg twice a day for 7-14 days;
• for the treatment of acne. It is prescribed in a dose of 500 mg for 2-4 weeks, 2 times a day. For maintenance therapy, it is recommended to take the drug for 8 weeks, 1 time per day, 500 mg.

Since Vilprafen Solutab effectively fights bacteria that have invaded the cell, the drug copes well with the treatment of bacterial prostatitis in men, the cause of which is mycoplasma, chlamydia, ureaplasma and treponema pale. Treatment with Vilprafen Solutab according to the instructions for prostatitis should last 10 days.

If the next dose of the drug is missed, you cannot take a double dose, as this can provoke an increase in the manifestation of side effects due to an overdose.

In the treatment of ureaplasmosis in men and women, it is necessary to use the Hexion solution to flush the urethra and vaginal suppositories Vaginorm, Ginolact, Hexion or Fermalak to restore the vaginal microflora and an antifungal drug, for example, Clotrimazole or Polygynax. It is important to remember that for effective treatment, it is necessary to constantly maintain the concentration of the active substance in the body and not to miss the next dose.

Vilprafen Solutab and its analogues

Drugs from the same group are called analogs or generics, so their active ingredient may differ. When the question arises of replacing the drug Vilprafen Solutab, only a doctor has the right to analogs, focusing on the patient's health condition and the cause of the disease.

note

There are no synonymous Vilprofen Solutab analogues, that is, josamycin as an active ingredient in other preparations is not declared.

Instead of Vilprafen Solutaba, doctors most often prescribe Azithromycin (Azilid, Azitrus, Azitral, Sumamed, Zitrolide, Hemomycin, etc.), since he is a representative of the macrolide group of drugs. Among other analogs, Erythromycin, Roxithromycin (Brilid, Rulid, Elrox, Roxibit, etc.), Clarithromycin (Binoclar, Klabaks, Klacid, Claricin, Fromilid, etc.), Spiramycin (Rovamycin), Midecamycin (Macropen) are used.

Vilprafen Salutab is produced in Italy, the Netherlands and France, so the cost of the drug starts at 600 rubles per pack. Another antibiotic analogue of Vilprafen Saliutab approved in Russia is Vilprafen, the cost of which starts from 550 rubles. In Europe, drugs with the active ingredient josamycin are approved for use - Josalid, Josacine, Iosalide, Josamina, in Japan - Josamy. Vilprafen Solutab and its analogs are powerful antibiotics, so it is dangerous to be treated with them on your own.